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A comprehensive analysis of immunoglobulin heavy chain genes in the Bactrian camel (

Zuoxiang LIANG,Tao WANG,Yi SUN,Wenlong YANG,Zhihong LIU,Jing FEI,Ying GUO,Qingwei MA,Qingjie PAN,Liming REN

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 3,   Pages 249-259 doi: 10.15302/J-FASE-2015056

Abstract: Heavy chain only antibodies (HCAbs) represent a rare type of antibody that is devoid of light chainstranscript data and genome sequences, we conducted a comprehensive analysis of Bactrian camel immunoglobulin heavychain genes.Additionally, the variable region of HCAbs (VHH) and the conventional antibodies (VH) sequences associated

Keywords： Bactrian camel     heavy-chain antibodies     VHH     γ3    

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of conventional mature B cells and compromised specific antibody response in bovine immunoglobulin μ heavy-chain

Min ZHANG,Xueqian CHENG,Dan CHU,Jingwen LIANG,Yi SUN,Li MA,Beilei XU,Min ZHENG,Meili WANG,Liming REN,Xiaoxiang HU,Qingyong MENG,Ran ZHANG,Ying GUO,Yunping DAI,Robert AITKEN,Ning LI,Yaofeng ZHAO

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 158-173 doi: 10.15302/J-FASE-2014015

Abstract: In this study, we introduced the bovine immunoglobulin μ heavy-chain gene (the orphaned gene on BTA11selected transgenic lines, and it largely inhibited rearrangements of the endogenous immunoglobulin heavychain (IgH) genes in these lines.

Keywords： bovine Ig μ heavy-chain     transgenic mice     B cell development     allelic exclusion     immune response     Ig repertoire    

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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Frontiers of Medicine   Pages 957-971 doi: 10.1007/s11684-023-0988-8

Abstract: Dynein axonemal heavy chain 10 (DNAH10) encodes a subunit of the inner arm dynein heavy chain

Keywords： DNAH10     mice     motile cilia     mutation     primary ciliary dyskinesia    

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of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human heavychain and the rat light chain

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 584-595 doi: 10.1007/s11684-021-0844-7

Abstract: Plasmids containing human FVIII heavy chain (hHC), human light chain (hLC), and rat light chain (rLC)

Keywords： hemophilia A     adeno-associated virus (AAV)     human/rat hybrid factor VIII     gene therapy     dual chain strategy    

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Development of the expressed immunoglobulin μ chain repertoire during maturation of mice B cells

Jingwen LIANG,Yingfeng LUO,Yi SUN,Meng LEI,Bing ZHANG,Songnian HU,Yaofeng ZHAO

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3,   Pages 201-213 doi: 10.15302/J-FASE-2014017

Abstract: To gain insight into the shift of the immunoglobulin heavy (IgH) chain repertoire during B cell development, we undertook large scale Ig μ chain repertoire analysis of pre-B, immature B and spleen B cell populationsAll these data indicated that the expressed Ig μ chain repertoire, especially the repertoire of CDRH3

Keywords： repertoire     complementarity determining region 3 of the IgH chain (CDRH3)     immunoglobulin     heavy chain     variable    

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Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 30-42 doi: 10.1007/s11684-019-0721-9

Abstract: Recent discoveries in broadly neutralizing monoclonal antibodies (bNAbs) has led to the development of

Keywords： HIV-1     broadly neutralizing antibodies     Env conformational states     vaccine design     SOSIP    

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Human monoclonal antibodies as candidate therapeutics against emerging viruses

Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 462-470 doi: 10.1007/s11684-017-0596-6

Abstract: Monoclonal antibodies (mAbs) have been successfully used to treat various diseases, particularly cancer

Keywords： human monoclonal antibodies     emerging infectious diseases     SARS-CoV     MERS-CoV     Ebola virus    

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Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in

Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 149-159 doi: 10.1007/s11684-020-0764-y

Abstract: Moreover, designing a universal influenza vaccine that is sufficiently immunogenic to induce universal antibodieshidden in the hemagglutinin (HA) trimeric interface have been discovered recently, and a number of antibodiesIn this review, we focused on the antibodies targeting these newly discovered epitopes in the HA domainof the influenza virus to promote the development of universal anti-influenza antibodies or vaccines

Keywords： influenza virus     neutralizing antibody     hemagglutinin     globular head region     trimeric interface    

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Synthesis of haptens and production of antibodies to bisphenol A

Xiya ZHANG, Xiaoyun DONG, Sijun ZHAO, Yuebin KE, Kai WEN, Suxia ZHANG, Zhanhui WANG, Jianzhong SHEN

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 366-372 doi: 10.15302/J-FASE-2017132

Abstract: bisphenol A (BPA), including two new haptens, were used to produce highly sensitive and specific polyclonal antibodiesHighly sensitive polyclonal antibodies were obtained and characterized using indirect competitive enzyme-linked

Keywords： bisphenol A     cross-reactivity     hapten     indirect competitive ELISA     polyclonal antibody    

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Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection

Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 746-751 doi: 10.1007/s11684-020-0822-5

Abstract: Here we examined, using ELISA, the IgG antibodies in serum specimens collected from 17 COVID-19 patients

Keywords： SARS-CoV-2     neutralizing antibodies     T-cell response    

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Characterization of polyclonal antibodies against nonstructural protein 9 from the porcine reproductive

Mengmeng ZHAO,Juanjuan QIAN,Jiexiong XIE,Tiantian CUI,Songling FENG,Guoqiang WANG,Ruining WANG,Guihong ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 153-160 doi: 10.15302/J-FASE-2016097

Abstract: Antibodies against 9 will be of great importance for the diagnosis and treatment of the causal agentA study was undertaken to generate polyclonal antibodies against the immunodominant 9.

Keywords： PRRSV     Nsp9     expression     antibody     neutralize    

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Co-pyrolysis of sludge and kaolin/zeolite in a rotary kiln: Analysis of stabilizing heavy metals

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 7, doi: 10.1007/s11783-021-1488-1

Abstract:

• Adding kaolin/zeolite promotes the formation of stable heavy metals

Keywords： Co-pyrolysis     Sewage sludge     Heavy metals     Rotary kiln     Immobilization mechanism    

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The biopharmaceutical industry in China: history and future perspectives

Kai Gao, Junzhi Wang

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 101-111 doi: 10.1007/s11684-012-0191-9

Abstract:

Biopharmaceuticals reflect the rapid progress achieved in modern biomedical research. This area has also become one of the main criteria for assessing the development level of biotechnology for a particular country. Although it has been only three decades since the first biopharmaceutical, recombinant human insulin, was licensed by the US Food and Drug Administration, the biopharmaceutical industry has become the fastest growing, most dynamic and technology-intensive sector in the biomedical field. Since the licensing of recombinant human interferon α1b in 1989, the biopharmaceutical industry in China has gone through initial developments and gradually entered a period of rapid growth. This paper provides an overview of the status and development trends of biopharmaceuticals in China, and compares them with those observed in developed countries.

Keywords： biopharmaceuticals     antibodies     market trends     diseases     China     national regulatory agency    

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Effects of sulfur on variations in the chemical speciation of heavy metals from fly ash glass

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 10, doi: 10.1007/s11783-023-1728-7

Abstract:

● A higher sulfur content reduced the curing rate of Cr in glass.

Keywords： Dechlorinated fly ash     SO3     Heavy metal     Chemical speciation     Glass solidification    

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Pricing and production strategies in remanufacturing from the perspectives of supply chain: Review and

Frontiers of Engineering Management doi: 10.1007/s42524-023-0251-7

Abstract: literature on pricing and production strategies in remanufacturing from four perspectives of supply chain, namely, government policy, consumer characteristics, relationships among firms, and supply chain structures

Keywords： remanufacturing     reverse and closed-loop supply chain     circular economy    

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Title Author Date Type Operation

A comprehensive analysis of immunoglobulin heavy chain genes in the Bactrian camel (

Zuoxiang LIANG,Tao WANG,Yi SUN,Wenlong YANG,Zhihong LIU,Jing FEI,Ying GUO,Qingwei MA,Qingjie PAN,Liming REN

Journal Article

of conventional mature B cells and compromised specific antibody response in bovine immunoglobulin μ heavy-chain

Min ZHANG,Xueqian CHENG,Dan CHU,Jingwen LIANG,Yi SUN,Li MA,Beilei XU,Min ZHENG,Meili WANG,Liming REN,Xiaoxiang HU,Qingyong MENG,Ran ZHANG,Ying GUO,Yunping DAI,Robert AITKEN,Ning LI,Yaofeng ZHAO

Journal Article

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Journal Article

of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human heavychain and the rat light chain

Journal Article

Development of the expressed immunoglobulin μ chain repertoire during maturation of mice B cells

Jingwen LIANG,Yingfeng LUO,Yi SUN,Meng LEI,Bing ZHANG,Songnian HU,Yaofeng ZHAO

Journal Article

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Journal Article

Human monoclonal antibodies as candidate therapeutics against emerging viruses

Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying

Journal Article

Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in

Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying

Journal Article

Synthesis of haptens and production of antibodies to bisphenol A

Xiya ZHANG, Xiaoyun DONG, Sijun ZHAO, Yuebin KE, Kai WEN, Suxia ZHANG, Zhanhui WANG, Jianzhong SHEN

Journal Article

Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection

Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen

Journal Article

Characterization of polyclonal antibodies against nonstructural protein 9 from the porcine reproductive

Mengmeng ZHAO,Juanjuan QIAN,Jiexiong XIE,Tiantian CUI,Songling FENG,Guoqiang WANG,Ruining WANG,Guihong ZHANG

Journal Article

Co-pyrolysis of sludge and kaolin/zeolite in a rotary kiln: Analysis of stabilizing heavy metals

Journal Article

The biopharmaceutical industry in China: history and future perspectives

Kai Gao, Junzhi Wang

Journal Article

Effects of sulfur on variations in the chemical speciation of heavy metals from fly ash glass

Journal Article

Pricing and production strategies in remanufacturing from the perspectives of supply chain: Review and

Journal Article